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Lacritin is a 12.3 kDa glycoprotein encoded in humans by the LACRT gene. Lacritin is a secreted protein found in tears and saliva. Lacritin also promotes tear secretion and proliferation of some epithelial cells. Lacritin is thus a prosecretory mitogen. Most lacritin is produced by the lacrimal gland. Some lacritin is produced by the meibomian gland, and also by epithelial cells of the conjunctiva and cornea. Together these epithelia comprise much of the lacrimal functional unit (LFU). Dry eye is the most common disease of the LFU. Preliminary studies with small trials suggest that lacritin may be differentially downregulated in dry eye. Topical lacritin promotes tearing in rabbit preclinical studies. Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. A G-protein coupled receptor (GPCR) then appears to be ligated. Targeted cells signal to NFAT and mTOR. Lacritin Abbreviation LACRT Sources lacrimal, meibomian and salivary glands; corneal and conjunctival epithelia Targets epithelial specificity Receptors syndecan-1 (SDC1 but not SDC2 or SDC4) as coreceptor; requires active heparanase (HPSE) to expose a protein core binding site; Signaling receptor: a GPCR is suspected (lacritin mitogenic signaling is pertussis toxin inhibitable); Site of Binding: between N-terminus of SDC1 and C-terminus of lacritin preclinical studies suggest utility in increasing ocular tearingFrom Wikipedia under the
GNU Free Documentation License  virginia.edu 614px x 597px | 95.50kB [source page] Parent Directory Greek Symbols Gifs 15 May 2002 11 09 Lacritin LacrimalGla > 02 Jan 2003 16 17 96K LacritinGeneStructur > 02 Jan 2003 16 17 95K  jmu.edu 268px x 400px | 59.40kB [source page] lacritin mckown JPG 18 Apr 2005 14 45 60K Sand jpg 24 Apr 2006 11 38 60K Student in car jpg 24 Apr 2006 15 37 59K PosterDougCAA14 JPG 25 Apr 2006 08 34 58K  jmu.edu 265px x 800px | 88.40kB [source page] maune2 jpg 25 Jan 2006 14 43 89K MadScholarcover JPG 18 Apr 2005 16 46 89K DNR Jump 800 JPG 06 Sep 2006 15 42 88K lacritin Raab JPG 18 Apr 2005 14 45 83K From Yahoo Image Search: "Lacritin"  dryeyedigest.blogspot.com Rebecca Wed, 23 Sep 2009 13:16:01 GM In summary across the approaches used, extracellular proteins identified to be altered included beta-2 microglobulin, proline rich 4, . lacritin. , and secretoglobin 1D1, which were found to be decreased in the dry eye state. ...  bcellphones.com J. Angelo Racoma Mon, 16 Oct 2006 02:05:42 GM tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, . lacritin. , immunoglobulins, glucose, urea, sodium, and potassium. this should probably serve as a warning to the ueber-emotional. either get a hands-free kit or a ...  oh samsara20 Sat, 15 Nov 2008 18:06:41 GM adrenocorticotropic hormone, and leucine enkephalin (a natural painkiller) than basal or reflex tears which contain mucin, lipids, lysozyme, lactoferrin, lipocalin, . lacritin. , immunoglobulins, glucose, urea, sodium, and potassium. ... From Google Blog Search: "Lacritin" |
