Lacritin is a 12.3 kDa glycoprotein encoded in humans by the LACRT gene. Lacritin is a secreted protein found in tears and saliva. Lacritin also promotes tear secretion and proliferation of some epithelial cells. Lacritin is thus a prosecretory mitogen.

Most lacritin is produced by the lacrimal gland. Some lacritin is produced by the meibomian gland, and also by epithelial cells of the conjunctiva and cornea. Together these epithelia comprise much of the lacrimal functional unit (LFU). Dry eye is the most common disease of the LFU. Preliminary studies with small trials suggest that lacritin may be differentially downregulated in dry eye. Topical lacritin promotes tearing in rabbit preclinical studies.

Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. A G-protein coupled receptor (GPCR) then appears to be ligated. Targeted cells signal to NFAT and mTOR.

Lacritin Abbreviation LACRT Sources lacrimal, meibomian and salivary glands; corneal and conjunctival epithelia Targets epithelial specificity Receptors syndecan-1 (SDC1 but not SDC2 or SDC4) as coreceptor; requires active heparanase (HPSE) to expose a protein core binding site; Signaling receptor: a GPCR is suspected (lacritin mitogenic signaling is pertussis toxin inhibitable); Site of Binding: between N-terminus of SDC1 and C-terminus of lacritin preclinical studies suggest utility in increasing ocular tearing

From Wikipedia under the GNU Free Documentation License
Sat Nov 7 12:16:46 2009

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From Yahoo Image Search: "Lacritin"
Tue Sep 15 14:54:09 2009

all about tears
sciencetips.com
all about tears

admin

Fri, 24 Oct 2008 18:25:02 GM

the aqueous layer is the middle layer, ehich contains water and substances like proteins (for example, tear lipocalin, . lacritin. , lysozyme, and lactoferrin) produced by the lacrimal gland. this layer serves to spread the tear film, ...

and the king cried
mafi.org.ph
and the king cried

admin

Mon, 23 Jun 2008 08:20:29 GM

tear fluid contains water, mucin lipids, lysozyme, lactoferrin, lipocalin, . lacritin. , immuno globulis, glucose, urea, sodium and potassium. in mammalian eyes the cornea is kept wet and nourished by basal tears. they lubricate the eye and ...

a theory of lachrymation
angblognibatotoy.blogspot.com
a theory of lachrymation

Batotoy

ue, 03 Feb 2009 03:50:00 GM

yung natitira ay binubuo ng mga substance tulad ng oils, tear lipocalin, lactoferrin, lysozyme, . lacritin. at mucin. maraming kategorya rin o klase ang luha. basal tears, relfex tears, at psychic tears. ikaw na bahala mag-research sa ...

From Google Blog Search: "Lacritin"
Sat Nov 7 12:15:57 2009